Drug Discovery Platform of the Research Institute of the MUHC

McGill University Health Centre, Montréal, Québec
What the facility does

Structure-based drug design, synthesis and analytical support to discover promising new therapeutics

Area(s) of Expertise

The Drug Discovery Platform provides structure-based drug design and synthetic support to researchers. With our drug discovery expertise and state-of-the-art analytical instrument facilities, we identify and validate promising new biological and chemical entities (including biomarkers) for life-threatening diseases. The new therapeutic entities then undergo a series of optimization processes to deliver drug candidates (CDs) which may ultimately lead to clinical trials. We provide access and training to users from both academia and industry on a broad range of cutting-edge technologies. 

Research Services

Chemistry, including structure-based drug design; nuclear magnetic resonance, including characterization of natural products, metabolomics and analysis of biopsies; mass spectrometry, including characterization of drug metabolites and pharmacokinetics and high-resolution tissue imaging on the basis of molecular weight; analysis of X-ray crystal structures; elemental analysis of drug substances; measurement of optical rotation; spectrometry; experimental design and consultation, training, extended assistance and demonstration on instrumentation.

Sectors of Application
  • Life sciences, pharmaceuticals and medical equipment

Name of specialized lab

Name of equipment in use

Description of function

Drug Discovery Platform equipment

Bruker hyphenated LC-NMR (600 MHz)-MS instrument

Coupled with a UHR-QqTOF spectrometer and Gilson liquid handler. Magic-angle spinning probe for solid state biopsies

 

Bruker Ascend™ NMR 400 MHz

Automated sample changer. RT, BBFOPLUS probes. Multinuclear broadband cryoprobe. Routine analysis of chemical entities

 

Bruker EVOQQube 

Triple Quadrupole mass spectrometer

Atmospheric ionization allows fastest high sensitive quantitative analysis in various applications

 

Bruker amaZon SL mass spectrometer

Routine mass analysis for synthetic samples

 

UltrafleXtreme MALDI-TOF/TOF mass spectrometer

Spatial distribution of metabolites. LC-MALDI proteomics, high-resolution tissue imaging, top-down sequencing

 

D8 QUEST system X-ray diffractometer

Effective analysis of extremely small crystals. Diffraction pattern of powder (non-crystalline)

 

Elementar Carbon-Hydrogen-Nitrogen (CHN) elemental microanalyser

Elemental analysis of drug substances

 

Jasco Circular Dichroism Spectrometer

Structural studies of small drug molecules, proteins and DNA

 

Agilent Cary 5000 UV-Vis-NIR spectrophotometer

High-performance UV-Vis-NIR spectrophotometer with photometric performance in the 175-3300 nm range

 

  • McGill University
  • Institut national de la recherche scientifique (INRS)
  • Institut de recherche en Immunologie et en cancérologie (IRIC)