Integrated preclinical drug discovery platform targeting human stem cells.
The institute consists of a single footprint that focuses on the development of innovative, large-scale drug discovery and drug safety evaluation platforms using human stem cells from multiple sources; the identification of compounds for treatment of cancer using our proprietary cancer stem cell technology; and the development of novel stem cell-based disease modelling strategies to support drug discovery and treatment decisions.
- human stem cell assays,
- high content imaging,
- high-throughput flow cytometry,
- image phenotype profiling,
- small molecule screening,
- pre-clinical in vivo disease modelling,
- in vitro disease modelling
Specialized labs and equipment
Specialized lab |
Equipment |
Function |
---|---|---|
David Braley Human Stem Cell Screening Facility (DBHSCF) |
Nikon Biostation CT |
Long-term live cell imaging |
|
Cellomics Arrayscan VTI |
High content screening microscope |
|
Perkin Elmer Operetta |
High content screening microscope |
|
Perkin Elmer Columbus and Acapella |
Image store and analysis database |
|
IDBS ActivityBase |
Drug screening database |
|
Thermo Biobank |
Compound management store |
|
BMG PHERAstar FS |
Multimode plate reader |
|
Hamilton Nimbus in BSC |
BSL2 liquid handling robot |
Stem Cell Isolation and Analysis Facility |
BD LSR II with high-throughput sampler |
High-throughput flow cytometer |
|
BD FACS Aria 2 |
High speed sorter |
Live Stem Cell Bank |
Thermo Cryoplus4 Cryotanks with environmental monitoring |
Long-term cell banking for primary patient samples |
|
Dotmatics Database |
Data integration database for screening, sample management and tertiary assays |
Private and public sector research partners
- High Throughput Screening Lab and Natural Products Lab (McMaster University)
- Michael DeGroote Institute for Infectious Disease Research (McMaster University)
- Hamilton Health Sciences
- Ottawa Health Research Institute
- London Health Sciences
- Centre for Commercialization of Regenerative Medicine
Additional information
Title |
URL |
---|---|
CBC: McMaster researchers zone in on 'best performing' bone marrow stem cells |
http://www.cbc.ca/hamilton/news/story/2013/08/01/hamilton-bone-marrow-research.html |
Globe and Mail: Drug could attack 'the root' of cancer cells: study
|