David Braley Human Stem Cell Screening Facility

McMaster University, Hamilton, Ontario
What the facility does

Integrated preclinical drug discovery platform targeting human stem cells.

Area(s) of Expertise

The institute consists of a single footprint that focuses on the development of innovative, large-scale drug discovery and drug safety evaluation platforms using human  stem cells from multiple sources; the identification of compounds for treatment of cancer using our proprietary cancer stem cell technology; and the development of novel stem cell-based disease modelling strategies to support drug discovery and treatment decisions.

Research Services
  • human stem cell assays,
  • high content imaging,
  • high-throughput flow cytometry,
  • image phenotype profiling,
  • small molecule screening,
  • pre-clinical in vivo disease modelling,
  • in vitro disease modelling

Name of specialized lab

Name of equipment

Description of function

David Braley Human Stem Cell Screening Facility (DBHSCF)

Nikon Biostation CT

Long-term live cell imaging

 

Cellomics Arrayscan VTI

High content screening microscope

 

Perkin Elmer Operetta

High content screening microscope

 

Perkin Elmer Columbus and Acapella

Image store and analysis database

 

IDBS ActivityBase

Drug screening database

 

Thermo Biobank

Compound management store

 

BMG PHERAstar FS

Multimode plate reader

 

Hamilton Nimbus in BSC

BSL2 liquid handling robot

Stem Cell Isolation and Analysis Facility

BD LSR II with high-throughput sampler

High-throughput flow cytometer

 

BD FACS Aria 2

High speed sorter

Live Stem Cell Bank

Thermo Cryoplus4 Cryotanks with environmental monitoring

Long-term cell banking for primary patient samples

 

Dotmatics Database

Data integration database for screening, sample management and tertiary assays

  • High Throughput Screening Lab and Natural Products Lab (McMaster University)
  • Michael DeGroote Institute for Infectious Disease Research (McMaster University)
  • Hamilton Health Sciences
  • Ottawa Health Research Institute
  • London Health Sciences
  • Centre for Commercialization of Regenerative Medicine

Title

URL

CBC: McMaster researchers zone in on 'best performing' bone marrow stem cells

http://www.cbc.ca/hamilton/news/story/2013/08/01/hamilton-bone-marrow-research.html

Globe and Mail: Drug could attack 'the root' of cancer cells: study

 

http://www.theglobeandmail.com/life/health-and-fitness/health/conditions/drug-could-attack-the-root-of-cancer-cells-study/article4209643/