Developmental molecular genetics research unit

Université du Québec à Montréal, Montréal, Québec
What the facility does

Research on normal and pathological nervous system development.

Area(s) of Expertise

Our laboratory’s research focuses primarily on the study of the development of the peripheral nervous system, using mice as the study model. We stand out thanks to our ability to generate genetically modified mice models that are unique in the world. These models are used to improve understanding of the molecular mechanisms responsible for severe congenital malformations such as aganglionic megacolon (Hirschsprung’s disease). Our work should lead to better screening, diagnosis and even treatment of congenital malformation diseases.

Research Services

Molecular biology, cellular biology, tissue culture, photonic microscopy, 3D fluorescence microscopy

Sectors of Application
  • Life sciences, pharmaceuticals and medical equipment

Name of equipment

Leica M205FA microscope

Leica M125 microscope

Leica DM2000 microscope

Thermo HM650V vibration microtome

Biological safety cabinets

CO2 incubators

Title

URL

A quantitative cell migration assay for murine enteric neural progenitors.

http://www.jove.com/video/50709/a-quantitative-cell-migration-assay-for-murine-enteric-neural

Characterization of a novel transgenic mouse line expressing Cre recombinase under the control of the Cdx2 neural specific enhancer.

http://onlinelibrary.wiley.com/doi/10.1002/dvg.22421/abstract;jsessionid=7EBF2CDC9460187DCC48D283C1FAF160.f02t01

The developmental genetics of Hirschsprung's disease.

http://onlinelibrary.wiley.com/doi/10.1111/cge.12032/abstract

Caudal-related homeobox (Cdx) protein-dependent integration of canonical Wnt signaling on paired-box 3 (Pax3) neural crest enhancer.

http://www.jbc.org/content/287/20/16623.long

A quantitative cell migration assay for murine enteric neural progenitors. http://www.jove.com/video/50709/a-quantitative-cell-migration-assay-for-murine-enteric-neural
Characterization of a novel transgenic mouse line expressing Cre recombinase under the control of the Cdx2 neural specific enhancer. http://onlinelibrary.wiley.com/doi/10.1002/dvg.22421/abstract;jsessionid=7EBF2CDC9460187DCC48D283C1…
The developmental genetics of Hirschsprung's disease. http://onlinelibrary.wiley.com/doi/10.1111/cge.12032/abstract
Caudal-related homeobox (Cdx) protein-dependent integration of canonical Wnt signaling on paired-box 3 (Pax3) neural crest enhancer. http://www.jbc.org/content/287/20/16623.long