What the facility does
State of the art small animal radiation platform for investigation of precision radiation and cancer immunotherapy in pre-clinical models
Areas of expertise
Immunotherapy, Radiation therapy, Cancer, Metabolism
The laboratory has a long-standing interest in delineating how metabolism impacts T cell immune responses. We employ a top-down approach whereby we study primary human biospecimens and further understand direct mechanisms of action using cell line and murine models. Our primary goal is to translate our findings into interventions that can be applied in the context of cancer immunotherapy, with a focus on ovarian and prostate cancer.
Research services
- On-board high-resolution cone beam-CT imaging and 3D reconstruction
- Image fusion
- Data Processing Analysis
- Whole body small animal radiation
- Dose planning
- Target micro beams (down to 0.5 mm)
- Radiation to an accuracy of 200 μm at clinically relevant dosing
- 3D volumetric image guidance
Sectors of application
- Healthcare and social services
- Life sciences, pharmaceuticals and medical equipment
- Professional and technical services (including legal services, architecture, engineering)
Specialized labs and equipment
| Equipment | Function |
|---|---|
| Small Animal Radiation Research Platform (SARRP) | Delivery of CT image guided radiation at clinically relevant dosing |
Private and public sector research partners
- AstraZeneca
- Genentech
- University of British Columbia
- BC Cancer
- University of Texas Southwestern Children’s Medical Center Research Institute
- University of Tokyo
- Tokushima University
- Osaka University
- Canada’s Michael Smith Genome Sciences Centre