Kerr Marine Natural Products Lab

University of Prince Edward Island, Charlottetown, Prince Edward Island
Area(s) of Expertise

The Kerr Marine Natural Products Lab has state-of-the-art equipment to conduct natural-product discovery research. The research group is composed of over 20 researchers and has outstanding expertise in both natural products isolation/characterization and microbiology. The combination of two LC-HRMS instruments hyphenated with ELSD and PDA detectors provides our lab with strong capabilities for the analysis of natural-product extracts, the quantification of targeted metabolites in environmental samples and the study of microbial secondary metabolomes using LC-HRMS assisted by statistical analyses.

What the facility does

Discovery of novel natural products from a marine microbial library with applications in human and animal health and wellness

Research Services

Isolation of natural products, structure elucidation, chemical analyses, including HRMS, cell and enzyme assays

Sectors of Application
  • Chemical industries
  • Health care and social services
  • Life sciences, pharmaceuticals and medical equipment
  • Ocean industries

Name of specialized lab

Name of equipment

Description of function

Kerr Marine Natural Products Lab

LC-HRMS-PDA-ELSD with an Exactive mass spectrometer (Thermo)

Chemical screening of natural products (NPs)

 

LC-HRMS-PDA with an LTQ-Velos (Thermo)

Quantification and identification of natural products (MSn)

 

LC-PDA-ELSD (Thermo)

Semi-preparative purification of NPs

 

LC-PDA-ELSD sample manager (Thermo)

Semi-preparative purification of NPs with automated fraction collection

 

GC-MS (Thermo)

Volatile compound analysis

 

Combiflash Rf200 (Teledyne)

Automated low-pressure purification

 

Evaporating systems: rotavap, Genevac

Drying samples

 

Polatrimeter Rudolph Autopol III

Optical rotation measurement

 

Shaking incubators, PCR units

Microbial fermentation

 

Biosafety cabinets

Microbial fermentation

 

Multi-mode plate reader

Bioassay

 

Freeze-dryer

Drying aqueous samples

  • Nautilus Biosciences
  • Croda
  • AB Vista
  • Cargill
  • Eisai
  • Dalhousie University
  • Ruhr University Bochum
  • Technical University of Munich