Maynes Lab

The Hospital for Sick Children, Toronto, Ontario
What the facility does

Cardiac and cardiomyocyte therapy and drug testing, cardiotoxicity testing, drug discovery

Area(s) of Expertise

In order to develop new cardiac therapies and predict pre-clinical cardiac drug toxicity, the effect of pharmaceuticals on cardiac and cardiomyocyte function needs to be measured in ways that translate accurately to patient response. At the Maynes Lab, we specialize in models of human heart function, using human patient and stem-cell- derived tissue constructs, including the development of novel platforms for high-throughput quantification of drug activity. Using these technologies and methodology, we can determine the comprehensive effects of drugs on human cardiac/cardiomyocyte activity either for therapy discovery or to predict drug toxicity.

Research Services

Cardiac tissue modeling, pre-clinical drug testing or development, prediction of drug cardiac activity for therapy discovery or for toxicity.

Sectors of Application
  • Life sciences, pharmaceuticals and medical equipment

Equipment

Function

xCELLigence RTCA Cardio ECR System

Arrhythmia testing

Environment chamber

Cardiomyocyte/iPSC experimentation in customized atmospheres (i.e. hypoxia)