Sherbrooke Molecular Imaging Centre (CIMS) of the Sherbrooke University Hospital Research Centre (CRCHUS)

Université de Sherbrooke, Sherbrooke, Québec
What the facility does

Preclinical imaging platform (PET, CT, MRI, optical), radiochemistry and development of new imaging technologies

Areas of expertise

The centre provides researchers and the industry with a unique range of preclinical and clinical imaging technologies. It has recognized expertise in positron emission tomography (PET), X-ray computed tomography (CT), magnetic resonance imaging (MRI) and optical imaging. With two cyclotrons and its radiochemistry service, the centre offers a wide range of radiotracers (C-11, N-13, F-18, Cu-64, Tc-99m) and radiopharmaceuticals (FDG, FTHA, acetate, acetoacetate, carvedilol, PIB). The centre’s laboratories are also actively involved in developing new preclinical imagers and new pharmaceutical agents for preclinical and clinical imaging (radiotracers, contrast mediums and optical probes). The centre has all of the infrastructure required for in vitro and in vivo validation (in animals and in clinical environments). Its clinical work serves a large population, and it is actively involved in research on oncology, cardiology, metabolism and neurology.

Research services

Our research expertise focuses on both animals and humans:

  • Radiochemistry service that offers biomolecule labelling with different radiotracers. Measurement of the in vitro and in vivo stability of radiopharmaceuticals including biodistribution studies.
  • Preclinical and clinical imaging (PET, SPECT, CT, MRI and optical imaging).
  • Monitoring of cardiac function and metabolism by PET/CT/MRI. Cerebral imaging. Therapeutic monitoring in murine and xenograft cancer models. Imaging assessments of new drugs.
  • Pharmacokinetics analysis and image processing service using an image analysis and visualization platform.
  • Animal facilities for housing small- and medium-sized animals on location.
  • Instrumentation and engineering component that works on developing new scanners and medical devices.
Sectors of application
  • Healthcare and social services
  • Life sciences, pharmaceuticals and medical equipment
Specialized lab Equipment Function
Preclinical imaging Triumph™ 8 cm PET/SPECT/CT Functional and anatomical imaging of small animals
  LabPET™ 4 cm PET Functional imaging of small animals
  LabPET™ II PET/SPECT Functional and anatomical imaging of small animals
  Optima™ SPECT Functional imaging of big and small animals
  Varian™ 7 t MRI Magnetic resonance imaging of small animals
  QOS™ optical imager Functional and anatomical imaging of small animals
  Hidex Automatic Gamma Counter Biodistribution analysis
Preclinical services Animal facilities with ventilated carriers (Level II certified) Housing on site
  SAITA 3 Digital animal files
Clinical imaging Philips™ Gemini GXL Functional and anatomical imaging of humans
  Philips™ Gemini TF Functional and anatomical imaging of humans
  Philips™ Ingenia 3 t MRI Magnetic resonance imaging of humans
  Siemens™ 1.5 t MRI Magnetic resonance imaging of humans
Cyclotrons EBCO/ACSI TR-19 Production of radioisotopes
  ACSI TR-24 Production of radioisotopes
Radiochemistry 3 clean rooms Health Canada certifications
  Radiosynthesis units  
  Hot cells  
  Quality control laboratory  
  Analytical equipment (HPLC, UPLC, MS)  
  Organic chemistry laboratory  
Instrumentation Computer cluster Image reconstruction and processing
  PET/SPECT scanner simulators Scanner development
  Instrumentation laboratory Design of detectors, scanners and medical devices
  Mechanical workshop  
  • Charles River Laboratories Inc.
  • iPST
  • Medtronic
  • AngioTox (EU-FP7)
  • Université de Montréal
  • Montreal Heart Institute
  • Institut universitaire de cardiologie et de pneumologie de Québec
Title URL
Research... fundamental for health | Au coeur de la vie 2014
Spotlight on Sherbrooke (3:00 to 4:23 min)
Manning Innovation Awards 2012