Discovery of novel natural products from a marine microbial library with applications in human and animal health and wellness
The Kerr Marine Natural Products Lab has state-of-the-art equipment to conduct natural-product discovery research. The research group is composed of over 20 researchers and has outstanding expertise in both natural products isolation/characterization and microbiology. The combination of two LC-HRMS instruments hyphenated with ELSD and PDA detectors provides our lab with strong capabilities for the analysis of natural-product extracts, the quantification of targeted metabolites in environmental samples and the study of microbial secondary metabolomes using LC-HRMS assisted by statistical analyses.
Isolation of natural products, structure elucidation, chemical analyses, including HRMS, cell and enzyme assays
- Chemical industries
- Healthcare and social services
- Life sciences, pharmaceuticals and medical equipment
- Ocean industries
Specialized labs and equipment
Equipment |
Function |
---|---|
LC-HRMS-PDA-ELSD with an Exactive mass spectrometer (Thermo) |
Chemical screening of natural products (NPs) |
LC-HRMS-PDA with an LTQ-Velos (Thermo) |
Quantification and identification of natural products (MSn) |
LC-PDA-ELSD (Thermo) |
Semi-preparative purification of NPs |
LC-PDA-ELSD sample manager (Thermo) |
Semi-preparative purification of NPs with automated fraction collection |
GC-MS (Thermo) |
Volatile compound analysis |
Combiflash Rf200 (Teledyne) |
Automated low-pressure purification |
Evaporating systems: rotavap, Genevac |
Drying samples |
Polatrimeter Rudolph Autopol III |
Optical rotation measurement |
Shaking incubators, PCR units |
Microbial fermentation |
Biosafety cabinets |
Microbial fermentation |
Multi-mode plate reader |
Bioassay |
Freeze-dryer |
Drying aqueous samples |
Private and public sector research partners
- Nautilus Biosciences
- Croda
- AB Vista
- Cargill
- Eisai
- Dalhousie University
- Ruhr University Bochum
- Technical University of Munich