Zebrafish Research Facility

National Research Council Canada, Halifax, Nova Scotia
What the facility does

Innovative zebrafish research facility where a range of in vivo assays, methods and disease models for industry specific applications have been developed and validated.

Area(s) of Expertise

Our facility utilizes adults, juveniles and early developmental stages of the zebrafish model to identify and characterize bioactivity and evaluate toxicity. Genetic research indicates high conservation between zebrafish and human genomes, making it an ideal model for generating biologically relevant in vivo information on a range of test material. We provide customized testing models and methods for a range of substances including extracts, complex mixtures and purified compounds. We can accommodate collaborative research and testing services projects that focus on evaluating toxicological and pharmacological activity in the areas of natural health products and human health therapeutics. At between 0.1 and 1.0 per cent of the cost of traditional rodent models, the zebrafish provides a powerful model for helping companies prioritize their leads and uncover potential obstacles before reaching more expensive testing models and methods.

Our zebrafish facility allows our partners to develop tailored, cost-effective and time-sensitive industry testing methods, resulting in generating biologically relevant in vivo data more rapidly. Our facility allows for credible, cost-effective trials with high throughput at a reduced cost of testing compared to higher vertebrate models.

Research Services
  • Preclinical toxicity profiling
  • Identification of mechanism of action
  • Omics techniques
  • Pharmacological testing
  • Microscopy
  • High-throughput behavioural tracking
  • Bath, intravenous and intracerebroventricular administration
  • Testing feed and feed additives
Sectors of Application
  • Agriculture, animal science and food
  • Environmental technologies and related services
  • Fisheries and aquaculture
  • Life sciences, pharmaceuticals and medical equipment

Name of equipment in use

Description of function

Behavioural ZebraBox (Noldus)

Allows high throughput automated observation and tracking movements of zebrafish embryos, larvae and adults.

Behavioural ZebraBox (ViewPoint)

Allows high throughput automated observation and tracking movements of zebrafish embryos, larvae and adults.

Micropipette puller

To make microinjection needles for delivery in zebrafish embryos.