Electrochemistry and Biosensors Laboratory

Université de Sherbrooke, Sherbrooke, Québec
What the facility does

Studies the biophysics of recognition elements and their ligands when in solution or when attached to surfaces in order to develop electrochemical biosensors.

Areas of expertise

The lab’s infrastructure enables the characterization of biomolecules (proteins, oligonucleotides, etc.) and of the thermodynamics associated with their interactions with ligands to form complexes, both when free in solution and when attached to surfaces. This infrastructure allows us to work with very small amounts of material, which provides significant savings given that those materials are often valuable. It also enables the characterization of ligand binding kinetics to these biomolecules with unprecedented microsecond (µs) temporal resolution, further making it possible to obtain additional information on their function. Specifically, this infrastructure enables state-of-the-art biophysical characterization of biomolecules. We rely on these biomolecules to then develop biosensors that can readily be deployed in undiluted complex matrices. To characterize biosensors, we rely on infrastructure that enables precise delivery and removal of ligands, making it possible, in turn, to determine biomolecular affinity with high precision.

Research services

Study of interactions between recognition elements (biomolecules) and their ligands in solution using calorimetry. Small quantities of material are required for conducting this type of study.

Sectors of application
  • Life sciences, pharmaceuticals and medical equipment



TA Instruments Affinity Isothermal Titration Calorimeter (ITC) Low Volume

Measure temperature changes in small volumes (<300 µL).

Affinité Instruments Portable SPR (Surface Plasmon Resonance)

Measure refractive index changes near a prism functionalized with a receptor.

BioLogic SFM-2000 stopped-flow mixing system

Quickly mix liquids (µs).

Implen NanoPhotometer NP80

Acquire absorbance spectra in small volumes.

Water purification system

For ion-free and contaminant-free water.

Hamilton ML-600 Automatic Titrator

Automated and synchronized delivery of small volumes in coordination with other instruments.

Keysight 33512B arbitrary waveform generator

Generate complex waves.


  • Abaxial Médical Inc.
  • CMC Microsystems
  • Colgate-Palmolive
  • Nutromics