Centre for Pharmaceutical Oncology

University of Toronto, Toronto, Ontario
What the facility does

Development of molecular diagnostics and therapeutics for cancer.

Area(s) of Expertise

The Centre for Pharmaceutical Oncology aims to bridge the gap between fundamental discoveries in cancer biology and first-in-humans clinical trials of new diagnostics and therapeutics for cancer by providing expertise in pharmaceutical science. Areas of expertise include: identification of molecular targets on tumours, point-of-care molecular diagnostics, nanoparticle drug delivery systems, radiopharmaceutical synthesis and characterization, molecular imaging (SPECT and PET), radioimmunotherapy, experimental therapeutics, pharmaceutical formulation, radiation dosimetry, polymer chemistry, antibody-based diagnostics and therapeutics. The Centre promotes collaborations between basic cancer biologists, pharmaceutical scientists and clinical oncologists to improve the outcomes of cancer patients.

Research Services
  • Molecular target identification for design of diagnostics and therapeutics for cancer.
  • Design, synthesis and characterization of nanoparticle drug delivery systems for cancer.
  • Engineering of point-of-care molecular diagnostics for cancer.
  • Synthesis and characterization of radiopharmaceuticals for cancer imaging and therapy.
  • Pharmaceutical polymer synthesis and characterization for cancer drug delivery.
Sectors of Application
  • Life sciences, pharmaceuticals and medical equipment

Specialized lab

Equipment 

Function

Centre for Pharmaceutical Oncology

Mass spectrometer

Molecular target identification

 

HPLC system with diode array and ELS detectors

Pharmaceutical characterization including nanoparticle drug delivery systems

 

Multi-function plate reader with cell imaging capability

Molecular target evaluation; Pharmaceutical development.

 

Flow cytometer

Molecular target evaluation; Pharmaceutical development.

 

Liquid scintillation counter

Pharmaceutical development

 

Immunoelectrophoretic focusing (IEF) instrument

Polymer characterization

 

DLS plate reader

Pharmaceutical characterization including nanoparticle drug delivery systems

 

LC-MS chromatographic system

Pharmaceutical development

 

Refrigerated ultra-centrifuge

Molecular diagnostics development

 

Fluorescence inverted microscope

Molecular diagnostics development

STTARR Innovation Centre

Multimodality microSPECT/PET/CT imaging system

Radiopharmaceutical development