Laboratory for Drug Delivery and Biomaterials

University of Waterloo, Kitchener, Ontario
What the facility does

Pharmaceutical sciences, materials science, and engineering

Area(s) of Expertise

Our laboratory is focused on the development and characterization of nanoparticles, medical devices and biomaterials for drug delivery applications. Our technology platforms are designed to be customizable to enhance drug solubility, targeted delivery, and improved therapeutic efficacy. We have the experience and knowledge to develop pharmaceutical formulations for small molecule drugs, proteins/peptides, and nucleic acids. We also have the infrastructure to provide in vitro and in vivo characterization, for example physico-chemical drug properties, tissue biocompatibility, and imaging. 

Research Services

Fabrication of pharmaceutical formulations (nanoparticles, biodegradable gels, films, solid dosage forms), pharmaceutical formulations for difficult-to-solubilize drugs, pharmaceutical formulations(fast-acting, sustained drug release, stimuli-responsive, targeted drug delivery), pharmaceutical formulations (intravenous, subcutaneous/intramuscular, intraperitoneal, transdermal, oral, intravaginal, rectal delivery), in vitro 
characterization of pharmaceutical formulations (particle size, molecular weight, stability, drug release rates, cell toxicity studies), in vivo characterization of pharmaceutical formulations (rodent and rabbit models, tissue biocompatibility, pharmacokinetics studies, pharmacodynamics studies, rodent cancer models).

Sectors of Application
  • Aerospace and satellites
  • Agriculture, animal science and food
  • Automotive
  • Chemical industries
  • Clean technology
  • Construction (including building, civil engineering, specialty trades)
  • Consumer durables
  • Consumer non-durables
  • Defence and security industries
  • Energy (renewable and fossil)
  • Environmental technologies and related services
  • Fisheries and aquaculture
  • Forestry and forest-based industries
  • Healthcare and social services
  • Life sciences, pharmaceuticals and medical equipment
  • Manufacturing and processing
  • Mining, minerals and metals
  • Ocean industries
  • Utilities

Specialized facility 

Equipment

Function

Advanced Microbicide Research and Analysis Facility (AMRAF)

Malvern Panalytical NanoSight NS300 NTA (Nanoparticle Tracking Analysis)

Nanoparticle size and concentration

Advanced Microbicide Research and Analysis Facility (AMRAF)

Hot Melt injection molder

 

Fabrication of polymer medical devices from pre-designed aluminum molds

Advanced Microbicide Research and Analysis Facility (AMRAF)

SPEX 6770 Freezer/Mill

 

Cryogenic grinding and pulverizing of tough and/or temperature-sensitive samples

Advanced Microbicide Research and Analysis Facility (AMRAF)

Waters UHPLC System

Determination of the concentration of drug samples

Biologics Evaluation Facility

 

Biological safety cabinet and tissue culture incubator

Performing in vitro cell studies, including cytotoxicity, cell targeting, and drug uptake

Biologics Evaluation Facility

EVOS™ FL AUTO fluorescent microscope

Imaging adherent and suspension cells using phase contrast or fluorescence

Title

URL

Canadian Researchers Have Designed a Tool for Preventing HIV in Women

 

https://www.chatelaine.com/health/hiv-prevention-women/

Scientists Have Found a New Treatment for Chlamydia

https://nypost.com/2019/02/06/scientists-have-found-a-new-treatment-for-chlamydia/

 

3D Printing Could Revolutionize HIV Prevention Drug Delivery

https://www.theglobeandmail.com/business/adv/article-3-d-printing-could-revolutionize-hiv-prevention-drug-delivery/