Chan Lab (INBS)

University of Toronto, Toronto, Ontario
What the facility does

Development of nanotechnologies to diagnose and treat cancer and infectious diseases

Area(s) of Expertise

The objective of the Integrated Nanotechnology/Biomedical Sciences Laboratory (INBS) is to develop nanotechnologies to improve the diagnosis and treatment of cancer and infectious diseases (two of the deadliest diseases in the world).  We have expertise in designing and engineering nanoparticles, nanostructures, and nanomaterials; testing and using them in cells and animals and for detecting small biological molecules such as proteins and DNA; and we have started to integrate optical devices such as smartphones with nanotechnology to develop cheaper and more efficient diagnostic systems. 

Research Services

Nanoparticle synthesis, animal testing of drugs, development of diagnostic devices, materials analysis, cell culture research. 

Sectors of Application
  • Agriculture, animal science and food
  • Chemical industries
  • Defence and security industries
  • Education
  • Energy (renewable and fossil)
  • Environmental technologies and related services
  • Healthcare and social services
  • Life sciences, pharmaceuticals and medical equipment

Name of specialized lab

Name of equipment

Description of function

INBS

UV-visible spectrophotometer

Measures the absorbance properties of materials and chemicals

 

Fluorimeter

Measures the fluorescence properties of materials and chemicals

 

Kodak In-Vivo Multispectral Imaging System

Images fluorescence signals from animals

 

Malvern Zetasizer

Measures the size and surface charge of nanoparticles

 

NIR laser

Generation of heat from nanoparticles

 

Thermal camera

Measures heat from nanoparticles

 

Fluorescence microscopes

Images nanoparticle fluorescence properties on slides, cells, and animals

 

HPLC

Purifies nanoparticle bioconjugates

 

Probe sonicator

Makes polymeric nanoparticles

 

Glove box

Storage of air free chemicals

 

Flow focusing system

Makes beads

 

Ultracentrifuge

Purifies nanoparticles

 

High-throughput Clarity setup

Removes scattering molecules from tissues

 

Flow cytometer

Analyzes optical signals from beads and cells

  • Parvus Therapeutics Inc.
  • Vigilant Technology LLC

Title

URL

Nanoparticle exposure test developed by Canadian scientists

http://www.cbc.ca/news/technology/nanoparticle-exposure-test-developed-by-canadian-scientists-1.2649608

Glowing space mice show where quantum dots lodge

http://www.newscientist.com/article/dn25562-glowing-space-mice-show-where-quantum-dots-lodge.html#.VUD5T_BjHFg

DNAzymes and gold nanoparticles: a colorimetric assay for diagnostics in the field

http://phys.org/news/2013-02-dnazymes-gold-nanoparticles-colorimetric-assay.html

DNAzymes, gold nanoparticles and disease detection: an interview with Dr. Chan and Kyryl Zagorovsky, University of Toronto

http://www.news-medical.net/news/20130423/DNAzymes-gold-nanoparticles-and-disease-detection-an-interview-with-Dr-Chan-and-Kyryl-Zagorovsky-University-of-Toronto.aspx

Three glowing mice

http://www.rsc.org/chemistryworld/2014/05/three-glowing-mice-quantum-dot-nanoparticle-toxicity

Fast, cheap methods of diagnosing infectious disease? They're coming sooner than you think

http://www.theglobeandmail.com/life/health-and-fitness/health/fast-cheap-methods-of-diagnosing-infectious-disease-theyre-coming-sooner-than-you-think/article11792043/

DNA-built nanoparticles safely target cancer tumours

http://www.scienceworldreport.com/articles/12520/20140129/dna-built-nanoparticles-safely-target-cancer-tumours.htm

Breaking barriers

http://www.natureasia.com/en/research/highlight/9045

Gold & DNA cocktail can rapidly screen for malaria and other diseases

http://www.healthline.com/health-news/tech-gold-and-dna-screening-test-for-pathogens-030813#1

New rapid disease test uses DNA powder and gold nanoparticles

http://www.medicaldaily.com/new-rapid-disease-test-uses-dna-powder-and-gold-nanoparticles-244570