Laboratory for Functional Tissue Engineering

University of Toronto, Toronto, Ontario
What the facility does

Cardiac tissue engineering

Area(s) of Expertise

Each year, nearly 900,000 people in North America alone suffer from myocardial infarction. Tissue engineering may offer alternative treatment options or suitable models for studies of normal and pathological cardiac tissue function in vitro. Conventional tissue engineering approaches are limited by inadequate oxygen supply, lack of physical stimuli and absence of multiple cell types characteristic of the native myocardium.

The Laboratory for Functional Tissue Engineering works on several different projects that all fall under the umbrella of cardiac tissue engineering and regenerative medicine. We are focused on pursuing molecular mechanisms governing the formation of contractile cardiac tissue in vitro, as well as on practical strategies for treatment of myocardial infarction and heart failure through development of new biomaterials. We pursue the research programs alone (e.g. advanced bioreactors and cell tri-culture) or in collaboration with other principal investigators (e.g. microfluidic separation of heart cells).

Research Services

Testing, prototyping, analytical services

Sectors of Application
  • Education
  • Healthcare and social services
  • Life sciences, pharmaceuticals and medical equipment
  • Professional and technical services (including legal services, architecture, engineering)

Name of equipment

Description of function

Objet 260 Connex1 Stratasys

3D Printer

Formlabs

3D Printer

CryoStar NX50

Cryostat

BOSE ElectroForce 5200 BioDynamic Test Instrument

Mechanical testing machine

Olympic X-Cite Series 120

Fluorescence microscope

SpectraMax i3

Multi-mode microplate reader

FreeZone 2.5

Lyophilizer

Title

URL

The Ted Rogers Centre for Heart Research: Researchers Leading the Way

http://tedrogersresearch.ca/research-experts/

Engineering Improved Heart Fibres from Stem Cells

http://www.cheminst.ca/magazine/news/engineering-improved%C2%AD-heart-fibres-stem%C2%A0cells

New “Biowire” Technology Matures Human Heart by Mimicking Fetal Heart Rate

http://www.mdtmag.com/news/2013/06/new-biowire-technology-matures-human-heart-mimicking-fetal-heart-rate#.UdrfWuspfWp

‘Biowire’ Could be Major Step Toward Viable Cardiac Patches

http://www.cnet.com/news/biowire-could-be-major-step-toward-viable-cardiac-patches/

Frankenstein Technique Creates Mature Heart Cells

http://www.uhn.ca/corporate/News/Pages/Frankenstein_technique_matures_heart_cells.aspx

Can Frankenstein and a Baby’s Heartbeat Unlock the Mystery of Stem Cells?

http://www.healthcanal.com/medical-breakthroughs/40121-can-frankenstein-and-a-baby%E2%80%99s-heartbeat-unlock-the-mystery-of-stem-cells.html

Can Frankenstein and a Baby’s Heartbeat Unlock the Mystery of Stem Cells?

http://media.utoronto.ca/media-releases/new-biowire-technology-rapidly-matures-human-heart-cells-with-fetal-biomimicry/

New ‘Biowire’ Technology Matures Human Heart by Mimicking Fetal Heartrate

http://www.eurekalert.org/pub_releases/2013-06/uotf-nt062413.php

New Reliable Method to Create Human Cardiac Patches in Range of Sizes

http://topnews.ae/content/216762-new-reliable-method-create-human-cardiac-patches-range-sizes

Electric Pulse Enables Creation of Cardiac Patches

http://www.laboratoryequipment.com/news/2013/06/electric-pulse-enables-creation-cardiac-patches

Second Skin: University of Toronto Invention Offers Hope for Burn Victims

http://www.news.utoronto.ca/second-skin-u-t-invention-offers-hope-burn-victims?utm_source=Bulletin&utm_medium=Email&utm_content=Staff