Sleep, Sedation and Anesthetic Sciences

University of Toronto, Toronto, Ontario
What the facility does

Integrative physiology and neurophysiology

Area(s) of Expertise

Our research focuses on sleep and respiratory neurobiology, including sedative and anesthetic-induced respiratory and neural depression. The research approach is integrative and interdisciplinary, encompassing electrophysiology, neuropharmacology, cell biology, neuroanatomy, integrative neuroscience, respiratory physiology, and sophisticated in-vivo physiological studies unique to this laboratory. The studies also involve molecular biology and genetic manipulations of cells, receptors, ion channels and neurotransmitter systems in appropriate models. We assess normal function and the effects of models of disease on this function. The basic research resulting from this program is applicable to human medical conditions and will affect the treatment options for certain common sleep-related breathing problems and sleep disorders by identifying, testing and developing novel therapeutic approaches for sleep- and drug-induced respiratory depression. 

Research Services

Electrophysiology, neuropharmacology, cell biology, neuroanatomy, integrative neuroscience, respiratory physiology, in-vivo physiological studies, receptors, ion channels, neurotransmitters, microdialysis

Sectors of Application
  • Life sciences, pharmaceuticals and medical equipment

Name of specialized lab

Name of equipment

Description of function

In-vivo Recording of Sleep and Breathing

Electrophysiological signals and respiratory gas analyzers

Data acquisition systems

Computers

Animal housing units

Non-invasive measurement of breathing in rodents

In-vivo studies of sleep and breathing

In-vivo Manipulation of Brain Regions

Microdialysis in freely moving rodent models

In-vivo manipulation of brain regions

 

Stereotaxic Surgery

Stereotaxic equipment

Surgical equipment

Targeted in-vivo manipulation of brain regions

Biochemistry and Histology Facility

Biochemistry

Histology

 

  • Lilly Research Laboratories (Surrey UK)
  • University of Alberta
  • University of Virginia
  • University of Minnesota
  • The Hospital for Sick Children