Sleep, Sedation and Anesthetic Sciences

University of Toronto, Toronto, Ontario
What the facility does

Integrative physiology and neurophysiology

Areas of expertise

Our research focuses on sleep and respiratory neurobiology, including sedative and anesthetic-induced respiratory and neural depression. The research approach is integrative and interdisciplinary, encompassing electrophysiology, neuropharmacology, cell biology, neuroanatomy, integrative neuroscience, respiratory physiology, and sophisticated in-vivo physiological studies unique to this laboratory. The studies also involve molecular biology and genetic manipulations of cells, receptors, ion channels and neurotransmitter systems in appropriate models. We assess normal function and the effects of models of disease on this function. The basic research resulting from this program is applicable to human medical conditions and will affect the treatment options for certain common sleep-related breathing problems and sleep disorders by identifying, testing and developing novel therapeutic approaches for sleep- and drug-induced respiratory depression. 

Research services

Electrophysiology, neuropharmacology, cell biology, neuroanatomy, integrative neuroscience, respiratory physiology, in-vivo physiological studies, receptors, ion channels, neurotransmitters, microdialysis

Sectors of application
  • Life sciences, pharmaceuticals and medical equipment
Specialized labEquipmentFunction
In-vivo Recording of Sleep and Breathing

Electrophysiological signals and respiratory gas analyzers

Data acquisition systems


Animal housing units

Non-invasive measurement of breathing in rodents

In-vivo studies of sleep and breathing
In-vivo Manipulation of Brain RegionsMicrodialysis in freely moving rodent modelsIn-vivo manipulation of brain regions


Stereotaxic Surgery

Stereotaxic equipment

Surgical equipment

Targeted in-vivo manipulation of brain regions
Biochemistry and Histology Facility



  • Lilly Research Laboratories (Surrey UK)
  • University of Alberta
  • University of Virginia
  • University of Minnesota
  • The Hospital for Sick Children