What the facility does
Electrophysiology and neuropharmacology using human induced pluripotent stem cells (hiPSCs).
Areas of expertise
The Beazely Lab at the School of Pharmacy has expertise in electrophysiology, protein biochemistry, signal transduction, neurodegeneration, neurotransmitters, neurotrophic factors, receptor tyrosine kinases. We use cell lines, cultured primary murine neurons, and human induced pluripotent stem cell models.
Research services
Whole-cell electrophysiology with an expertise in NMDA (N-methyl-D-aspartate) receptor activity, multi-electrode array measurements of cultured neuronal networks, and protein biochemical analysis including protein expression, phosphorylation, trafficking, and intracellular signaling.
Sectors of application
- Healthcare and social services
- Life sciences, pharmaceuticals and medical equipment
Specialized labs and equipment
| Equipment | Function |
|---|---|
| Electrophysiology rig | Set up for primarily isolate whole-cell recordings. |
| Micro-electrode array system | |
| Fluorescence microscope | For qualitative immunocytochemistry and imaging. |
| Human induced pluripotent stem cell culture hood | |
| Incubator |
Additional information
| Title | URL |
|---|---|
| Chronic early-life social isolation affects NMDA and TrkB receptor expression in a sex-specific manner. | https://pubmed.ncbi.nlm.nih.gov/34111511/ |
| Amyloid-β inhibits PDGFβ receptor activation and prevents PDGF-BB-induced neuroprotection. | https://pubmed.ncbi.nlm.nih.gov/29332578/ |
| 5-Hydroxytryptamine type 7 receptor neuroprotection against NMDA-induced excitotoxicity is PDGFβ receptor dependent. | https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.12157 |