Characterization of biopolymers and soft materials.
The Optical Trapping Laboratory specializes in the mechanical characterization of individual molecules and microscale materials. Expertise ranges from single-molecule measurements to microrheology. The laboratory houses state-of-the-art instrumentation, including a centrifuge force microscope and optical trapping instruments, one a dynamic holographic optical tweezers instrument useful for characterizing soft materials (such as gels and matrices) that exhibit 2- and 3-dimensional microscale heterogeneity. In characterizing the growth of materials, expertise includes monitoring the development of viscoelastic heterogeneity at high bandwidth (>1 kHz) over time scales from seconds to hours. The comprehensive wet lab neighbouring the optical tweezers instrumentation means that biological and chemical samples can be prepared and characterized in-house.
Mechanical characterization of soft materials at the single-molecule and microscale levels.
- Agriculture, animal science and food
- Clean technology
- Life sciences, pharmaceuticals and medical equipment
- Manufacturing and processing
Specialized labs and equipment
- Optical trapping laboratory: Soft materials microrheology; monitoring spatially resolved development of viscoelasticity at the microscale; and single-molecule characterization (standard and dynamic holographic optical tweezers)
- High-throughput single-molecule manipulation laboratory: Force-dependent enzymatic cleavage, ligand-receptor interactions (centrifuge force microscope)
- Molecular biology laboratory: Cell culture facilities, microscopy facilities, fast protein liquid chromatography (FPLC), UV-Vis spectrophotometer, fluorescence plate reader, thermocycler, gel electrophoresis and blotting