Optical Trapping Laboratory

Simon Fraser University, Burnaby, British Columbia
What the facility does

Characterization of biopolymers and soft materials.

Areas of expertise

The Optical Trapping Laboratory specializes in the mechanical characterization of individual molecules and microscale materials. Expertise ranges from single-molecule measurements to microrheology. The laboratory houses state-of-the-art instrumentation, including a centrifuge force microscope and optical trapping instruments, one a dynamic holographic optical tweezers instrument useful for characterizing soft materials (such as gels and matrices) that exhibit 2- and 3-dimensional microscale heterogeneity.  In characterizing the growth of materials, expertise includes monitoring the development of viscoelastic heterogeneity at high bandwidth (>1 kHz) over time scales from seconds to hours. The comprehensive wet lab neighbouring the optical tweezers instrumentation means that biological and chemical samples can be prepared and characterized in-house.

Research services

Mechanical characterization of soft materials at the single-molecule and microscale levels.

Sectors of application
  • Agriculture, animal science and food
  • Clean technology
  • Life sciences, pharmaceuticals and medical equipment
  • Manufacturing and processing
  • Optical trapping laboratory: Soft materials microrheology; monitoring spatially resolved development of viscoelasticity at the microscale; and single-molecule characterization (standard and dynamic holographic optical tweezers)
  • High-throughput single-molecule manipulation laboratory: Force-dependent enzymatic cleavage, ligand-receptor interactions (centrifuge force microscope)
  • Molecular biology laboratory: Cell culture facilities, microscopy facilities, fast protein liquid chromatography (FPLC), UV-Vis spectrophotometer, fluorescence plate reader, thermocycler, gel electrophoresis and blotting