Pharmacokinetics core facility of the University of Montréal Hospital Research Centre

Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec
What the facility does

Our facility supports research in the quantification of xenobiotics and metabolites in biological matrices. We also specialize in determining drug metabolism.

Area(s) of Expertise

We are experts in bioanalysis with more than 20 years of experience in mass spectrometry and the analysis of drugs in biological matrices. The facility’s staff makes all its expertise in mass spectrometry and bioanalysis directly available to researchers and graduate students for the purposes of designing, carrying out and analyzing experiments. The facility is equipped with state-of-the-art instruments, including three triple quadrupoles (Thermo Quantiva and Thermo Ultra) and a hybrid quadrupole-orbitrap instrument (Thermo Q Exactive Plus) for high-resolution analysis. These instruments are equipped with liquid chromatographic interfaces (HPLC, UHPLC and nano LC). We have recognized expertise in developing, validating and carrying out analyses to specifically identify and quantify xenobiotics and metabolites in biological matrices.

Research Services

Service personalized to the specific objectives of each research project. Development and validation of innovative and effective analytical methods. Identification and characterization of xenobiotics and metabolites, quantification of xenobiotics and metabolites in biological fluids (blood, plasma, serum, CSF and urine) and more complex matrices (organs). Validation of analytical methods according to the highest quality standards in the industry (ICH and FDA). Sample preparation, extraction and injection, analysis of the results and production of a detailed analytical report.

Sectors of Application
  • Chemical industries
  • Life sciences, pharmaceuticals and medical equipment

Name of equipment in use

Description of function

Q Exactive Plus

Hybrid Quadrupole-OrbitrapTM Mass Spectrometer, high resolution/accurate mass

TSQ Quantiva

Triple quadrupole mass spectrometer

TSQ Quantum Ultra

Triple quadrupole mass spectrometer

Dionex UltiMate 3000 RSLC

UHPLC chromatography system

Dionex UltiMate 3000 RSLCnano

Nano LC chromatography system

Shimadzu Prominence UFLC

UFLC chromatography system

Shimadzu Prominence UV-VIS, Fluorescence

Detectors