Centre for Continuous Flow Synthesis

Université de Montréal, Montréal, Québec
What the facility does

The Centre for Continuous Flow Synthesis makes it possible to convert batch processes into continuous flow processes to synthesize molecules of interest in a safe and efficient way.

Area(s) of Expertise

Continuous flow chemistry is a revolutionary technique that facilitates organic molecule synthesis and analysis on both small and large scales. Although this technology is only gradually being accepted as the way of the future, it is an innovative, efficient and powerful approach for preparing molecules that traditionally involved multiple tedious and potentially dangerous steps. Unlike a conventional organic reaction, which is generally carried out in round-bottom flasks and batch reactors, continuous flow chemistry uses reactors made of tubes that enable chemicals to circulate continuously in solution throughout the reaction. Compared to conventional reactors, continuous flow reactors transfer heat and mass faster due to their compact dimensions and high surface-to-volume ratio. Reactions are therefore better controlled, creating a safer working environment. The use of continuous flow reactors also reduces reaction times and improves yields and selectivity. Therefore, continuous flow chemistry can be used to synthesize simple small-scale or industrial-scale target molecules as well as libraries of new molecules. This technology has been seriously evaluated by pharmaceutical and industrial R&D laboratories throughout the world for sustainable development, in particular because it offers numerous production advantages such as processes that are more efficient, safe, economical and environmentally friendly. The Centre for Continuous Flow Synthesis combines a variety of advanced continuous-flow instruments for the synthesis, purification and analysis of target molecules, all under the same roof. With the help of our highly skilled personnel, your batch processes can be converted into continuous flow streams, producing molecules of interest in a safe and effective way.

Research Services

Synthesis, analysis, purification, green chemistry, catalysis, continuous flow

Sectors of Application
  • Aerospace and satellites
  • Agriculture, animal science and food
  • Automotive
  • Chemical industries
  • Consumer durables
  • Consumer non-durables
  • Defense and security industries
  • Education
  • Life sciences, pharmaceuticals and medical equipment
  • Manufacturing and processing

Name of specialized lab

Name of equipment in use

 

ThalesNano H-Cube hydrogenation reactor

 

Voyager microwave stop-flow reactor

 

Uniqsis continuous flow reactors with automation and gas insertion modules

 

Vapourtec R1C, R2+ and R4 reactors equipped with cooling, automation and gas insertion modules

 

Syrris high efficiency Asia pumps

 

Zaiput advanced liquid-liquid and pressure separators

 

Luzchem photoreactors for continuous flow reactions using ultraviolet ionizing radiation

 

Customizable systems (with syringe pumps and various parts that can be combined and assembled by researchers) to mount unique and specialized devices for continuous flow processes

Regional Centre of NMR spectroscopy

Bruker ARX-400 NMR spectrometer for in situ microreactor reaction analysis and for batch sample analysis

Regional Mass Spectrometry Centre

 

Waters UPLC ion mobility quadrupole time-of-flight mass spectrometer to perform high-throughput analyses

 

OmniCal ultra-low-temperature microcalorimeter for molecule safety assessments