Capillary Electrophoresis Chromatographic Separation - Centre for Biologics Evaluation

Health Canada, Ottawa, Ontario
What the facility does

Separation science research on recombinant biotherapeutics, vaccines and biosimilars

Areas of expertise

The laboratory has expertise in separation sciences and analytical biotechnologies. Specifically, research and method development are performed to provide scientific guidance on protein based biologics used in drugs and pharmaceutical products. The laboratory is also proficient in the matter of biosimilars, glycoproteins and vaccines products.

Research services

The laboratory provides expertise in High-Performance Liquid Chromatography and Capillary Electrophoresis analytical applications through collaborative arrangements.

Sectors of application
  • Life sciences, pharmaceuticals and medical equipment



Waters Alliance High Performance Liquid Chromatography (HPLC) systems

HPLC system with PDA (Photodiode Array) and Fluorescence detector

SCIEX PA800 Plus Capillary Electrophoresis (CE) system


CE systems are equipped with UV, PDA and Laser-induced Fluorescence detector

SCIEX CESI Plus* Capillary Electrophoresis system


CESI Plus* can be coupled to MS system for mass detection

Bruker uTOF (micro Time of Flight) II Mass spectrometry system


European Directorate for Quality of Medicines Expert group 6



Biologics and Genetic Therapies Directorate…

Fast and highly selective determination of hemagglutinin content in quadrivalent influenza vaccine by reversed-phase high-performance liquid chromatography method. J Chromatrogr A.


NMR study of mutations of glycine-52 of the catalytic domain of diphtheria toxin. Pharm Biomed Anal


Dodecylphosphocholine Micelles Induce Amyloid Formation of PrP Peptide via α-Helical Metastable Conformation. PLOS ONE