Alberta Glycomics Centre

University of Alberta, Edmonton, Alberta
Area(s) of Expertise

The Alberta Glycomics Centre conducts basic and applied R&D in glycomics (carbohydrates) with a focus on finding novel solutions to industry issues in the areas of population health, personalized medicine, agriculture, food, environment, and quality of life. Specializing in microbial glycomics, the Centre uses an interdisciplinary approach to address research problems and welcomes new research collaboration opportunities. It also provides core services to industry and research partners, including glycan screening, structure analysis (mass spectrometry, NMR, molecular modelling), glycoengineering, and carbohydrate synthesis.

What the facility does

Development of carbohydrate-based compounds, drugs and vaccines

Research Services

Drug and vaccine development; drug discovery; carbohydrate synthesis; glycan structure-function analysis; glycan screening; glycoengineering

Sectors of Application
  • Agriculture, animal science and food
  • Chemical industries
  • Defense and security industries
  • Education
  • Health care and social services
  • Life sciences, pharmaceuticals and medical equipment

Name of equipment

Description of function

NMR 700 MHz spectroscopy

Identification of interactions and confirmation among molecules

NMR 600 MHz spectroscopy with upgrades for solid state capabilities

Analysis of glycan contents within the whole bacterial cell

NMR 500 MHz spectroscopy with upgrades for cryoprobe

 

MALDI-TOF-TOF mass spectrometer

Analysis of glycoproteins

TOF LC-MS system

Analysis of compounds and observations of changes

Waters Synapt G2 mass spectrometer

Determination of weak binding interactions between two compounds

FTICR mass spectrometer

Assessment of differences in mass among molecules and observations of changes, down to the atomic level, in chemical reactions

Electrospray ionization mass spectrometry (ESI-MS) instrumentation

Determining affinities of small molecules to proteins

Surface Plasmon Resonance

Monitoring binding events in real time without the use of labels

Inverted fluorescence microscope with photobleaching system

Study of interaction of fluorescence protein molecules in living cells and tissues

Inverted fluorescence microscope with TIRF excitation

Investigation of cell membrane and other surface processes in a direct manner

Solid-phase peptide synthesizer 

Synthesis of peptides by combining amino acids

Carbohydrate library (more than 250 compounds)

Library screening, drug discovery

  • Alberta Innovates
  • VaxAlta
  • Canadian Glycomics Network (GlycoNet)